Which statement about topical capsaicin cream is true?

• A. OTC analgesic that relieves minor pain like osteoarthritis
• B. A prescription-only analgesic
• C. Provides immediate relief with one application
• D. Should be applied to broken or irritated skin

Answer: (A)

Topical capsaicin works by depleting substance P in peripheral nerves, which reduces pain signals from the skin to the brain. Because this effect develops with repeated use, there isn’t immediate relief after one application. It is commonly available over the counter in low concentrations for treating minor pains, such as osteoarthritis, so the statement that it is an OTC analgesic for mild joint pain is true. It should not be applied to broken or irritated skin, since damaged skin can lead to increased burning and irritation. Use a thin layer on intact skin as directed, and wash hands after application to avoid irritation to eyes or mucous membranes.