NCLEX Uworld Practice Test

Duloxetine works by inhibiting the reuptake of serotonin and norepinephrine, increasing their levels in the synaptic cleft. This dual action helps improve mood in depression and also reduces pain perception, which is why it’s used for both depressive disorders and certain chronic pain conditions. It is not a stimulant like amphetamine, nor a benzodiazepine. It does not decrease serotonin levels; it increases them by blocking reabsorption. Common considerations include potential side effects such as nausea, dry mouth, dizziness, and possible blood pressure elevation, plus caution with other serotonergic drugs due to the risk of serotonin syndrome.