Which physical finding is commonly associated with infectious mononucleosis?

• A. Jaundice
• B. Hypertension
• C. Chest pain
• D. Splenomegaly

Answer: (D)

Infectious mononucleosis commonly causes the spleen to enlarge as part of the immune response to the Epstein-Barr virus. Splenomegaly is a hallmark physical finding because the spleen becomes reactive and swollen, sometimes with left upper-quadrant fullness or tenderness. This finding helps distinguish mono from other illnesses and has important implications, such as advising against contact sports or heavy lifting to reduce the risk of splenic rupture during the illness.

Jaundice can occur if the liver is involved, but it is not as consistently seen as splenomegaly. Chest pain and hypertension are not typical features of infectious mononucleosis, so they’re less supportive of this diagnosis.