Which of the following is a sign of digoxin toxicity?

• A. Hypertension
• B. Visual changes
• C. Weight gain
• D. Headache

Answer: (B)

Visual changes are a classic sign of digoxin toxicity. Digoxin can affect the retina and the nervous system, leading to color perception distortions and blurred vision, often described as seeing yellow or green halos around lights. This visual disturbance is particularly characteristic and helps distinguish digoxin toxicity from other problems.

Other common features of toxicity can include GI symptoms like nausea and vomiting and CNS symptoms such as confusion or dizziness, and the drug can cause bradycardia or various conduction abnormalities. However, hypertension, weight gain, or headaches are not as specifically associated with digoxin toxicity, so they’re less informative in identifying this condition. If toxicity is suspected, it’s important to hold the medication, check the serum digoxin level, and assess electrolytes, with appropriate management as guided by a clinician.