Which mood-related symptom is associated with hypothyroidism?

• A. Depression and lethargy
• B. Hyperactivity
• C. Euphoria
• D. Anxiety with insomnia

Answer: (A)

The mood-related symptom associated with hypothyroidism is depression and lethargy. When thyroid hormone levels are low, the body's metabolism slows down, and this affects brain chemistry as well. Neurotransmitters like serotonin and norepinephrine can be disrupted, leading to a depressed mood, slower thinking, and reduced energy. People may seem tired, withdrawn, and less motivated, with sluggish speech and mental processes. This contrasts with other mood states such as hyperactivity or euphoria, which are more typical of hyperthyroidism or manic episodes, and with anxiety-related symptoms like insomnia, which are common in anxiety disorders or hyperthyroid states. Treating the thyroid deficiency with appropriate hormone replacement often improves mood and energy as metabolic and neurotransmitter balance are restored.