Where should epinephrine be administered in anaphylaxis?

• A. Intravenous infusion
• B. Intramuscular injection in the thigh
• C. Subcutaneous in the forearm
• D. Inhalation

Answer: (B)

The key idea here is that epinephrine must be absorbed quickly to counteract the airway swelling, bronchospasm, and dropping blood pressure that come with anaphylaxis, and the intramuscular route in the thigh achieves that fastest, most reliable absorption.

Administering epinephrine intramuscularly into the mid-thigh (the vastus lateralis area) provides rapid uptake into the bloodstream, producing a quick reversal of symptoms. Subcutaneous injections can be slower and less predictable in the setting of shock or poor perfusion. Intravenous administration is reserved for authorized hospital settings with close monitoring because it carries more risk of overdose and cardiac complications. Inhalation does not deliver enough systemic epinephrine to treat the whole-body reaction and isn’t appropriate as the primary treatment for anaphylaxis.