When 20-40 mEq of potassium chloride are needed, which access is preferred?

• A. Peripheral IV
• B. Central venous access device
• C. Intramuscular
• D. Subcutaneous

Answer: (B)

Large doses of potassium chloride require secure, central venous access to minimize tissue injury and allow safe administration. Potassium chloride is caustic to veins if it infiltrates around the IV site, so using a central line places the infusion into a large vein with rapid dilution, reducing the risk of phlebitis or tissue necrosis and supporting controlled delivery of 20–40 mEq. Peripheral veins are more prone to irritation and infiltration with higher-dose potassium, making them less safe for this amount. Intramuscular or subcutaneous routes are not appropriate because potassium chloride absorption is unpredictable and can cause severe local injury. So, a central venous access device offers safer, more reliable administration for sizeable potassium replacements.