What sign is typically seen in retinoblastoma?

• A. Red reflex is present.
• B. White reflex in the pupil.
• C. Enlarged cornea.
• D. Painful red eye.

Answer: (B)

Leukocoria, a white pupillary reflex, is the sign most commonly associated with retinoblastoma. When a mass develops in the retina, it reflects light differently from the normal red reflex, producing a white or chalky appearance in the pupil. This white reflex is often the first clue in a child and may be noticed as a white spot in photographs or by a parent during eye observations, sometimes alongside strabismus or decreased vision. In contrast, a normal red reflex suggests the eye is transmitting light as expected, while an enlarged cornea or a painful red eye points to other eye conditions such as glaucoma or inflammatory processes rather than retinoblastoma. If leukocoria is observed, urgent ophthalmology evaluation is essential.