What is the optimal neonatal glucose level range?

• A. 50-70 mg/dL
• B. 60-90 mg/dL
• C. 40-60 mg/dL
• D. 70-100 mg/dL

Answer: (D)

Maintaining neonatal glucose within a safe range is essential to protect the brain’s energy supply during the immediate postnatal transition. After birth, the baby shifts from maternal glucose to independent regulation, so glucose levels can dip. Aiming for about 70–100 mg/dL in a healthy term newborn provides enough energy to meet brain needs while avoiding the risks of both hypoglycemia and excess glucose.

If glucose falls into the lower range (around 40–60 mg/dL), this indicates potential hypoglycemia and usually prompts interventions such as more frequent feeds or IV dextrose if needed. Values higher than this range are not typically targeted in healthy infants, as hyperglycemia can also cause complications. Therefore, the 70–100 mg/dL range is the best target for a stable neonate.