What is a serious complication of statin therapy?

• A. Hypertension
• B. Anemia
• C. Rhabdomyolysis
• D. Hyperglycemia

Answer: (C)

Rhabdomyolysis is a serious complication of statin therapy. Statins can cause muscle cell injury, especially at higher doses or when paired with interacting drugs or conditions. When muscle fibers break down, myoglobin spills into the bloodstream. The kidneys try to filter this protein, but excessive myoglobin can overwhelm them and lead to acute kidney injury and electrolyte abnormalities. People may experience severe muscle pain or weakness, and sometimes dark urine from myoglobin in the urine. Lab tests typically show a very high creatine kinase level, with possible rising creatinine and potassium.

Because this reaction can be life-threatening, the immediate step is to stop the statin and assess kidney function and electrolytes. Aggressive IV hydration is important to protect the kidneys and promote clearance of myoglobin. Depending on severity, additional treatments or specialist care may be needed. After recovery, reintroducing statin therapy at a lower dose or exploring alternatives requires careful monitoring to prevent recurrence.