Parvovirus B19 infection is associated with which rash in children?

• A. Koplik spots
• B. Bull's-eye rash
• C. Slapped-cheek rash
• D. Strawberry tongue

Answer: (C)

Parvovirus B19 in kids typically presents with a bright red, slapped-cheek facial rash that may be followed by a lacy, reticular rash on the body. This “slapped-cheek” appearance is the classic clue for erythema infectiosum caused by parvovirus B19. The rash is most characteristic in children and often appears with mild fever or malaise before or as it develops.

Koplik spots are tiny white spots inside the mouth seen with measles, so that choice points to measles rather than parvovirus. A bull's-eye rash is associated with erythema migrans in Lyme disease (or can describe targetoid lesions in erythema multiforme), not this parvovirus presentation. Strawberry tongue is seen in scarlet fever or Kawasaki disease due to mucosal involvement, not parvovirus B19.

So, the slapped-cheek rash is the hallmark feature that links to Parvovirus B19 infection in children.